Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes.
Identifieur interne : 000592 ( Main/Exploration ); précédent : 000591; suivant : 000593Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes.
Auteurs : Jie Li [République populaire de Chine] ; Daniel Q. Huang [Singapour] ; Biyao Zou [États-Unis] ; Hongli Yang [République populaire de Chine] ; Wan Zi Hui [Singapour] ; Fajuan Rui [République populaire de Chine] ; Natasha Tang Sook Yee [Singapour] ; Chuanli Liu [République populaire de Chine] ; Sanjna Nilesh Nerurkar [Singapour] ; Justin Chua Ying Kai [Singapour] ; Margaret Li Peng Teng [Singapour] ; Xiaohe Li [République populaire de Chine] ; Hua Zeng [République populaire de Chine] ; John A. Borghi [États-Unis] ; Linda Henry [États-Unis] ; Ramsey Cheung [États-Unis] ; Mindie H. Nguyen [États-Unis]Source :
- Journal of medical virology [ 1096-9071 ] ; 2020.
Abstract
Coronavirus disease 2019 (COVID-19) has become a pandemic, but its reported characteristics and outcomes vary greatly amongst studies. We determined pooled estimates for clinical characteristics and outcomes in COVID-19 patients including subgroups by disease severity (based on World Health Organization Interim Guidance Report or Infectious Disease Society of America/American Thoracic Society criteria) and by country/region. We searched Pubmed, Embase, Scopus, Cochrane, Chinese Medical Journal, and preprint databases from 1 January 2020 to 6 April 2020. Studies of laboratory-confirmed COVID-19 patients with relevant data were included. Two reviewers independently performed study selection and data extraction. From 6007 articles, 212 studies from 11 countries/regions involving 281 461 individuals were analyzed. Overall, mean age was 46.7 years, 51.8% were male, 22.9% had severe disease, and mortality was 5.6%. Underlying immunosuppression, diabetes, and malignancy were most strongly associated with severe COVID-19 (coefficient = 53.9, 23.4, 23.4, respectively, all P < .0007), while older age, male gender, diabetes, and hypertension were also associated with higher mortality (coefficient = 0.05 per year, 5.1, 8.2, 6.99, respectively; P = .006-.0002). Gastrointestinal (nausea, vomiting, abdominal pain) and respiratory symptoms (shortness of breath, chest pain) were associated with severe COVID-19, while pneumonia and end-organ failure were associated with mortality. COVID-19 is associated with a severe disease course in about 23% and mortality in about 6% of infected persons. Individuals with comorbidities and clinical features associated with severity should be monitored closely, and preventive efforts should especially target those with diabetes, malignancy, and immunosuppression.
DOI: 10.1002/jmv.26424
PubMed: 32790106
PubMed Central: PMC7436673
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Chine</country><wicri:regionArea>Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Yee, Natasha Tang Sook" sort="Yee, Natasha Tang Sook" uniqKey="Yee N" first="Natasha Tang Sook" last="Yee">Natasha Tang Sook Yee</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Liu, Chuanli" sort="Liu, Chuanli" uniqKey="Liu C" first="Chuanli" last="Liu">Chuanli Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Nerurkar, Sanjna Nilesh" sort="Nerurkar, Sanjna Nilesh" uniqKey="Nerurkar S" first="Sanjna Nilesh" last="Nerurkar">Sanjna Nilesh Nerurkar</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Kai, Justin Chua Ying" sort="Kai, Justin Chua Ying" uniqKey="Kai J" first="Justin Chua Ying" last="Kai">Justin Chua Ying Kai</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Teng, Margaret Li Peng" sort="Teng, Margaret Li Peng" uniqKey="Teng M" first="Margaret Li Peng" last="Teng">Margaret Li Peng Teng</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital</wicri:regionArea><wicri:noRegion>National University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xiaohe" sort="Li, Xiaohe" uniqKey="Li X" first="Xiaohe" last="Li">Xiaohe Li</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Disease, The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Division of Infectious Disease, The Third People's Hospital of Shenzhen, Shenzhen, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Zeng, Hua" sort="Zeng, Hua" uniqKey="Zeng H" first="Hua" last="Zeng">Hua Zeng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Internal Medicine, School of Medicine, Shenzhen University, Shenzhen, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Borghi, John A" sort="Borghi, John A" uniqKey="Borghi J" first="John A" last="Borghi">John A. Borghi</name><affiliation wicri:level="2"><nlm:affiliation>Lane Medical Library, School of Medicine, Stanford University, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Lane Medical Library, School of Medicine, Stanford University, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Henry, Linda" sort="Henry, Linda" uniqKey="Henry L" first="Linda" last="Henry">Linda Henry</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Cheung, Ramsey" sort="Cheung, Ramsey" uniqKey="Cheung R" first="Ramsey" last="Cheung">Ramsey Cheung</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Veterans Affairs Palo Alto Health Care System, Palo Alto, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Gastroenterology and Hepatology, Veterans Affairs Palo Alto Health Care System, Palo Alto</wicri:cityArea></affiliation></author><author><name sortKey="Nguyen, Mindie H" sort="Nguyen, Mindie H" uniqKey="Nguyen M" first="Mindie H" last="Nguyen">Mindie H. Nguyen</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32790106</idno><idno type="pmid">32790106</idno><idno type="doi">10.1002/jmv.26424</idno><idno type="pmc">PMC7436673</idno><idno type="wicri:Area/Main/Corpus">000430</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000430</idno><idno type="wicri:Area/Main/Curation">000430</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000430</idno><idno type="wicri:Area/Main/Exploration">000430</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes.</title><author><name sortKey="Li, Jie" sort="Li, Jie" uniqKey="Li J" first="Jie" last="Li">Jie Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Cheeloo College of Medicine, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Cheeloo College of Medicine, Shandong Provincial Hospital, Shandong University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Daniel Q" sort="Huang, Daniel Q" uniqKey="Huang D" first="Daniel Q" last="Huang">Daniel Q. Huang</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital</wicri:regionArea><wicri:noRegion>National University Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Zou, Biyao" sort="Zou, Biyao" uniqKey="Zou B" first="Biyao" last="Zou">Biyao Zou</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Yang, Hongli" sort="Yang, Hongli" uniqKey="Yang H" first="Hongli" last="Yang">Hongli Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Cheeloo College of Medicine, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Cheeloo College of Medicine, Shandong Provincial Hospital, Shandong University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Hui, Wan Zi" sort="Hui, Wan Zi" uniqKey="Hui W" first="Wan Zi" last="Hui">Wan Zi Hui</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Rui, Fajuan" sort="Rui, Fajuan" uniqKey="Rui F" first="Fajuan" last="Rui">Fajuan Rui</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Yee, Natasha Tang Sook" sort="Yee, Natasha Tang Sook" uniqKey="Yee N" first="Natasha Tang Sook" last="Yee">Natasha Tang Sook Yee</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Liu, Chuanli" sort="Liu, Chuanli" uniqKey="Liu C" first="Chuanli" last="Liu">Chuanli Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Nerurkar, Sanjna Nilesh" sort="Nerurkar, Sanjna Nilesh" uniqKey="Nerurkar S" first="Sanjna Nilesh" last="Nerurkar">Sanjna Nilesh Nerurkar</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Kai, Justin Chua Ying" sort="Kai, Justin Chua Ying" uniqKey="Kai J" first="Justin Chua Ying" last="Kai">Justin Chua Ying Kai</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Teng, Margaret Li Peng" sort="Teng, Margaret Li Peng" uniqKey="Teng M" first="Margaret Li Peng" last="Teng">Margaret Li Peng Teng</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital</wicri:regionArea><wicri:noRegion>National University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xiaohe" sort="Li, Xiaohe" uniqKey="Li X" first="Xiaohe" last="Li">Xiaohe Li</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Disease, The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Division of Infectious Disease, The Third People's Hospital of Shenzhen, Shenzhen, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Zeng, Hua" sort="Zeng, Hua" uniqKey="Zeng H" first="Hua" last="Zeng">Hua Zeng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Internal Medicine, School of Medicine, Shenzhen University, Shenzhen, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Borghi, John A" sort="Borghi, John A" uniqKey="Borghi J" first="John A" last="Borghi">John A. Borghi</name><affiliation wicri:level="2"><nlm:affiliation>Lane Medical Library, School of Medicine, Stanford University, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Lane Medical Library, School of Medicine, Stanford University, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Henry, Linda" sort="Henry, Linda" uniqKey="Henry L" first="Linda" last="Henry">Linda Henry</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Cheung, Ramsey" sort="Cheung, Ramsey" uniqKey="Cheung R" first="Ramsey" last="Cheung">Ramsey Cheung</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Veterans Affairs Palo Alto Health Care System, Palo Alto, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Gastroenterology and Hepatology, Veterans Affairs Palo Alto Health Care System, Palo Alto</wicri:cityArea></affiliation></author><author><name sortKey="Nguyen, Mindie H" sort="Nguyen, Mindie H" uniqKey="Nguyen M" first="Mindie H" last="Nguyen">Mindie H. Nguyen</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of medical virology</title><idno type="eISSN">1096-9071</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronavirus disease 2019 (COVID-19) has become a pandemic, but its reported characteristics and outcomes vary greatly amongst studies. We determined pooled estimates for clinical characteristics and outcomes in COVID-19 patients including subgroups by disease severity (based on World Health Organization Interim Guidance Report or Infectious Disease Society of America/American Thoracic Society criteria) and by country/region. We searched Pubmed, Embase, Scopus, Cochrane, Chinese Medical Journal, and preprint databases from 1 January 2020 to 6 April 2020. Studies of laboratory-confirmed COVID-19 patients with relevant data were included. Two reviewers independently performed study selection and data extraction. From 6007 articles, 212 studies from 11 countries/regions involving 281 461 individuals were analyzed. Overall, mean age was 46.7 years, 51.8% were male, 22.9% had severe disease, and mortality was 5.6%. Underlying immunosuppression, diabetes, and malignancy were most strongly associated with severe COVID-19 (coefficient = 53.9, 23.4, 23.4, respectively, all P < .0007), while older age, male gender, diabetes, and hypertension were also associated with higher mortality (coefficient = 0.05 per year, 5.1, 8.2, 6.99, respectively; P = .006-.0002). Gastrointestinal (nausea, vomiting, abdominal pain) and respiratory symptoms (shortness of breath, chest pain) were associated with severe COVID-19, while pneumonia and end-organ failure were associated with mortality. COVID-19 is associated with a severe disease course in about 23% and mortality in about 6% of infected persons. Individuals with comorbidities and clinical features associated with severity should be monitored closely, and preventive efforts should especially target those with diabetes, malignancy, and immunosuppression.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32790106</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-9071</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Aug</Month><Day>13</Day></PubDate></JournalIssue><Title>Journal of medical virology</Title><ISOAbbreviation>J Med Virol</ISOAbbreviation></Journal><ArticleTitle>Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1002/jmv.26424</ELocationID><Abstract><AbstractText>Coronavirus disease 2019 (COVID-19) has become a pandemic, but its reported characteristics and outcomes vary greatly amongst studies. We determined pooled estimates for clinical characteristics and outcomes in COVID-19 patients including subgroups by disease severity (based on World Health Organization Interim Guidance Report or Infectious Disease Society of America/American Thoracic Society criteria) and by country/region. We searched Pubmed, Embase, Scopus, Cochrane, Chinese Medical Journal, and preprint databases from 1 January 2020 to 6 April 2020. Studies of laboratory-confirmed COVID-19 patients with relevant data were included. Two reviewers independently performed study selection and data extraction. From 6007 articles, 212 studies from 11 countries/regions involving 281 461 individuals were analyzed. Overall, mean age was 46.7 years, 51.8% were male, 22.9% had severe disease, and mortality was 5.6%. Underlying immunosuppression, diabetes, and malignancy were most strongly associated with severe COVID-19 (coefficient = 53.9, 23.4, 23.4, respectively, all P < .0007), while older age, male gender, diabetes, and hypertension were also associated with higher mortality (coefficient = 0.05 per year, 5.1, 8.2, 6.99, respectively; P = .006-.0002). Gastrointestinal (nausea, vomiting, abdominal pain) and respiratory symptoms (shortness of breath, chest pain) were associated with severe COVID-19, while pneumonia and end-organ failure were associated with mortality. COVID-19 is associated with a severe disease course in about 23% and mortality in about 6% of infected persons. Individuals with comorbidities and clinical features associated with severity should be monitored closely, and preventive efforts should especially target those with diabetes, malignancy, and immunosuppression.</AbstractText><CopyrightInformation>© 2020 Wiley Periodicals LLC.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Jie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Infectious Disease, Cheeloo College of Medicine, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Daniel Q</ForeName><Initials>DQ</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zou</LastName><ForeName>Biyao</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Hongli</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Cheeloo College of Medicine, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hui</LastName><ForeName>Wan Zi</ForeName><Initials>WZ</Initials><AffiliationInfo><Affiliation>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rui</LastName><ForeName>Fajuan</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yee</LastName><ForeName>Natasha Tang Sook</ForeName><Initials>NTS</Initials><AffiliationInfo><Affiliation>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Chuanli</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nerurkar</LastName><ForeName>Sanjna Nilesh</ForeName><Initials>SN</Initials><AffiliationInfo><Affiliation>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kai</LastName><ForeName>Justin Chua Ying</ForeName><Initials>JCY</Initials><AffiliationInfo><Affiliation>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teng</LastName><ForeName>Margaret Li Peng</ForeName><Initials>MLP</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Xiaohe</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Division of Infectious Disease, The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeng</LastName><ForeName>Hua</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, School of Medicine, Shenzhen University, Shenzhen, Guangdong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borghi</LastName><ForeName>John A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Lane Medical Library, School of Medicine, Stanford University, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henry</LastName><ForeName>Linda</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheung</LastName><ForeName>Ramsey</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Veterans Affairs Palo Alto Health Care System, Palo Alto, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nguyen</LastName><ForeName>Mindie H</ForeName><Initials>MH</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-6275-4989</Identifier><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Med Virol</MedlineTA><NlmUniqueID>7705876</NlmUniqueID><ISSNLinking>0146-6615</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">clinical characteristics</Keyword><Keyword MajorTopicYN="N">mortality</Keyword><Keyword MajorTopicYN="N">risk factors</Keyword><Keyword MajorTopicYN="N">severe</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32790106</ArticleId><ArticleId IdType="doi">10.1002/jmv.26424</ArticleId><ArticleId IdType="pmc">PMC7436673</ArticleId></ArticleIdList><ReferenceList><Title>REFERENCES</Title><Reference><Citation>Cucinotta D, Vanelli M. 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JAMA. 2020;323(20):2052-2059.</Citation></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li><li>Singapour</li><li>États-Unis</li></country><region><li>Californie</li></region><orgName><li>Université nationale de Singapour</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, Jie" sort="Li, Jie" uniqKey="Li J" first="Jie" last="Li">Jie Li</name></noRegion><name sortKey="Li, Jie" sort="Li, Jie" uniqKey="Li J" first="Jie" last="Li">Jie Li</name><name sortKey="Li, Xiaohe" sort="Li, Xiaohe" uniqKey="Li X" first="Xiaohe" last="Li">Xiaohe Li</name><name sortKey="Liu, Chuanli" sort="Liu, Chuanli" uniqKey="Liu C" first="Chuanli" last="Liu">Chuanli Liu</name><name sortKey="Rui, Fajuan" sort="Rui, Fajuan" uniqKey="Rui F" first="Fajuan" last="Rui">Fajuan Rui</name><name sortKey="Yang, Hongli" sort="Yang, Hongli" uniqKey="Yang H" first="Hongli" last="Yang">Hongli Yang</name><name sortKey="Zeng, Hua" sort="Zeng, Hua" uniqKey="Zeng H" first="Hua" last="Zeng">Hua Zeng</name></country><country name="Singapour"><noRegion><name sortKey="Huang, Daniel Q" sort="Huang, Daniel Q" uniqKey="Huang D" first="Daniel Q" last="Huang">Daniel Q. Huang</name></noRegion><name sortKey="Huang, Daniel Q" sort="Huang, Daniel Q" uniqKey="Huang D" first="Daniel Q" last="Huang">Daniel Q. Huang</name><name sortKey="Hui, Wan Zi" sort="Hui, Wan Zi" uniqKey="Hui W" first="Wan Zi" last="Hui">Wan Zi Hui</name><name sortKey="Kai, Justin Chua Ying" sort="Kai, Justin Chua Ying" uniqKey="Kai J" first="Justin Chua Ying" last="Kai">Justin Chua Ying Kai</name><name sortKey="Nerurkar, Sanjna Nilesh" sort="Nerurkar, Sanjna Nilesh" uniqKey="Nerurkar S" first="Sanjna Nilesh" last="Nerurkar">Sanjna Nilesh Nerurkar</name><name sortKey="Teng, Margaret Li Peng" sort="Teng, Margaret Li Peng" uniqKey="Teng M" first="Margaret Li Peng" last="Teng">Margaret Li Peng Teng</name><name sortKey="Yee, Natasha Tang Sook" sort="Yee, Natasha Tang Sook" uniqKey="Yee N" first="Natasha Tang Sook" last="Yee">Natasha Tang Sook Yee</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Zou, Biyao" sort="Zou, Biyao" uniqKey="Zou B" first="Biyao" last="Zou">Biyao Zou</name></region><name sortKey="Borghi, John A" sort="Borghi, John A" uniqKey="Borghi J" first="John A" last="Borghi">John A. Borghi</name><name sortKey="Cheung, Ramsey" sort="Cheung, Ramsey" uniqKey="Cheung R" first="Ramsey" last="Cheung">Ramsey Cheung</name><name sortKey="Cheung, Ramsey" sort="Cheung, Ramsey" uniqKey="Cheung R" first="Ramsey" last="Cheung">Ramsey Cheung</name><name sortKey="Henry, Linda" sort="Henry, Linda" uniqKey="Henry L" first="Linda" last="Henry">Linda Henry</name><name sortKey="Nguyen, Mindie H" sort="Nguyen, Mindie H" uniqKey="Nguyen M" first="Mindie H" last="Nguyen">Mindie H. Nguyen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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